Bose-Einstein Condensate (BEC) is considered the coldest substance of the universe while quark gluon plasma (QGP) is considered the hottest substance of the universe. It is natural to assume that BEC can be found in interstellar space. However, the uniform temperature of outer space is approximately 2.7 K as the minimum of the CBR (cosmic background radiation). Unless the absolute temperature is practically zero BEC cannot exist. On the other hand, it is natural to assume that QGP can be found in the interior of stars. The hotter the star the more likely QGP can be found in its interior. Since the heat of any star is derived from thermonuclear fusion, its heat capacity is much lower than what is needed for QGP to exist. Therefore, as far as extreme temperature is concerned both BEC and QGP cannot be found naturally anywhere in the universe except at the big bang singularity for QGP and the heat death of the universe at absolute zero for BEC. Somewhere between BEC and QGP lies the reality of all living life forms.