Recently professor in physics and Nobelprizewinner Gerard 't Hooft said in an interview, when reflecting on the possibility of a Theory of everything: "Explaining the smallest particles of the Mount Everest isn't explaining the Mount Everest."
And why's that ?
One could say: explaing the bricks the house is made of isn't explaining the house.
Or: explaining Oxygen and Hydrogen of H2O isn't explaining waves and vortexes, behaviour of clouds, etcetera.
Or: explaining biochemical processess in the brain isn't explaining for instance The Ring der Nibulungen.
Etcetera. And so on.
Science speaks in all these cases of emergence: new order pops up on higher levels of complexity. Thus making the explanation of 'everything' out of strings, quarks, gravity, etcetera, highly unlikely. Nature says No. Empirical experience says No. The facts say No.
Secondly, science has by definition a fragmented view on reality.
For instance physics only looks at the physical phenomena, chemistry only looks at the chemical phenomena, biology only..., psychology, sociology, economy only... etcetera. They all try to describe only a certain part of reality, and aren't really interested in what is going on in all the other parts and respective sciences. Each in themselves have a kind of blindness concerning the reality as a whole, while exactly this whole has to be adressed when speaking on a Theory of everything. The only science that has an eye for everything, by definition, by tradition, already for more then twothousand years and more, is philosophy.
Only philosophy can try to integrate and organize all information the sciences are giving us, in order to give a picture of the whole, a maybe plausible story on why it is there, this reality, on what is its purpose, meaning, general coherence, direction, et cetera.
It would give a real Theory of everything. As Aristotle would say: a First Philosophy.
But it is eager reductionism (Dannett) that diehard holds the focus on particles in trying to explain the Mount Everest.


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